About one-third of people with epilepsy will eventually develop refractory epilepsy. People with epilepsy have seizures due to abnormal electrical activity in the brain. What causes refractory epilepsy? Refractory Epilepsy: Causes, Risk Factors, Treatment And Role Of Keto Diet. This means that medicines don't work well, or at all, to control the seizures. By Amritha K. on February 17, 2020 | Reviewed By Karthika Thirugnanam. Facts about refractory epilepsy Refractory epilepsy … These seizures may last a few seconds or a few minutes. Some seizures have known causes, such as head injuries, infections, fevers, or brain tumors. In the same way, it is not clear why some people with epilepsy … Research shows that up to 40 percent of people who have epilepsy will eventually develop intractable epilepsy, also called drug-resistant epilepsy or refractory epilepsy. But often the cause of seizures in epilepsy is not known. This section presents many of the causes of apparently refractory seizures for which seizures are potentially treatable, or that actually reflect other underlying conditions that require other treatment … Some seizures have known causes, such as head injuries, infections, fevers, or brain tumors. A seizure … In the same way, it is not clear why some people with epilepsy … What causes refractory epilepsy? This means medication no longer works well enough to control their episodes, and their seizures are frequent, severe, and affecting their quality of life. But often the cause of seizures in epilepsy is not known.